Natural Aldose Reductase Inhibitors Act as Potent Agonists of PPARγ

Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties.

Amorfrutins are isoprenoid-substituted benzoic acid derivatives, which were found in Amorpha fruticosa L. (bastard indigo) and in Glycyrrhiza foetida Desf. (licorice). Recently, amorfrutins were shown to be selective activators of the nuclear receptor PPARγ. Here, we investigated the effects and PPARγ-based mechanisms of reducing inflammation in colon cells by treatment with amorfrutins. In TNF...

Aldose Reductase Inhibitors as Potential Therapeutic Drugs of Diabetic Complications

Diabetes mellitus has become a major health threat as a global rise in it has been seen. The chronic disease has afflicted over 171 million people worldwide in 2000 and the incidence is expected to grow steadily to 366 million by 2030. As of May 2008, an estimated 92 million adults in China of the most populous country were living with diabetes and 148 million adults with prediabetes [1]. Diabe...

Screening of Natural Compounds as Matrix Metalloproteinase and Aldose Reductase Inhibitors: Drug Design for Diabetic Retinopathy

Diabetic retinopathy (DR) is a micro-vascular complication of diabetes and one of the leading causes of blindness. Two of the possible candidate PROTEINS contributing to the development of diabetic retinopathy are aldose reductase (AR) and Matrix metalloproteinase-2 (MMP2). In the current study plant derived medicinal compounds and chemical compounds are studied by Docking analysis that are car...

Current status of aldose reductase inhibitors.

Selective irreversible inhibitors of aldose reductase.

A series of 5-substituted-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid analogues have been examined as irreversible inhibitors of aldose reductase. The 5-alpha-bromoacetamide and 5-alpha-iodoacetamide analogues 5 and 6 gave irreversible inhibition of aldose reductase while the 5-alpha-chloroacetamide analogue 3 did not show this type of inhibition. Protection studies indicate that irreve...